Proinflammatory Status, Genetics and Atherosclerosis

Authors: R. Poledne, A. Lorenzová, P. Stávek, Zdeněk Valenta, J. Hubáček, R. Suchánek, J. Piťha
Publication year: 2009
Publication type: Článek v odborném periodiku
Periodical: Physiological Research
Projects: Centre of Biomedical Informatics
Bibliographic citation: POLEDNE, R., LORENZOVÁ, A., STÁVEK, P., VALENTA, Zdeněk, HUBÁČEK, J., SUCHÁNEK, R., PIŤHA, J. Proinflammatory Status, Genetics and Atherosclerosis. Physiological Research. 2009, 58(Suppl. 2), S111-S118. ISSN 0862-8408. E-ISSN 1802-9973
Dostupné z: doi:10.33549/physiolres.931915.
DOI: 10.33549/physiolres.931915
ID: 343802

Abstract

C-reactive protein concentration analyzed by high sensitivity method (hsCRP) represents a known marker of premature atherosclerosis. Higher concentrations represent an increased individual risk of myocardial infarction and stroke. In a representative sample of the Czech population, a positive relation of hsCRP to BMI, a waist circumference and triglyceride concentration was documented. Substantial sex differences were found in its relationship to age. Whereas it is continuously increasing in men, this increase appears in women only after menopause. A substantial decrease of body weight and visceral fat volume by increased physical activity is accompanied by significant decrease of hsCRP in young obese women. We hypothesized that an increased concentration of hsCRP represents a certain marker of proinflammatory status related to central obesity and triglyceride metabolism and it might be related to individual properties of monocytes in atherogenesis