Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

Authors: A. Stádníková, L. Ďuďáková, P. Skalická, Zdeněk Valenta, M. Filipec, K. Jirsová
Publication year: 2017
Publication type: Článek v odborném periodiku
Periodical: PLoS ONE
Bibliographic citation: STÁDNÍKOVÁ, A., ĎUĎÁKOVÁ, L., SKALICKÁ, P., VALENTA, Zdeněk, FILIPEC, M., JIRSOVÁ, K. Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients. PLoS ONE. 2017, 12(4), e0175509. ISSN 1932-6203. E-ISSN 1932-6203
Dostupné z: doi:10.1371/journal.pone.0175509
DOI: 10.1371/journal.pone.0175509
ID: 474103

Abstract

Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.