Olfactory Dysfunction in Narcolepsy with and without Cataplexy

Autoři: RNDr. Jan Klaschka, Ph.D.
Rok vydání: 2010
Typ publikace: Článek v odborném periodiku
Periodikum: Sleep Medicine
Bibliografická citace: BUŠKOVÁ, J., KLASCHKA, Jan, ŠONKA, K., NEVŠÍMALOVÁ, S. Olfactory Dysfunction in Narcolepsy with and without Cataplexy. Sleep Medicine. 2010, 11(6), 558-561. ISSN 1389-9457. E-ISSN 1878-5506
Dostupné z: doi:10.1016/j.sleep.2010.01.009
DOI: 10.1016/j.sleep.2010.01.009
ID: 343526

Abstrakt

Not only patients in whom REM behavior disorder (RBD) is associated with narcolepsy, but also those with narcolepsy alone are reported to have olfactory dysfunction. We investigated if hyposmia is specific to narcolepsy with cataplexy (N-C) or if narcolepsy without cataplexy (NwC) is also associated with olfactory dysfunction. We studied olfactory function in two groups of patients: N-C group (n = 66), and NwC group (n = 17). As a control group we used published normative data for particular smell tests. Both patients with N-C and NwC had a significantly higher olfactory threshold and impaired odor identification. Our results show for the first time that narcolepsy without cataplexy, where the majority of cases have normal CSF hypocretin levels, is associated with olfactory dysfunction. It appears that also a partial loss of hypothalamic hypocretin neurons without a clear CSF level decrease can affect smell projection.