High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro

Autoři: RNDr. Milan Paluš, Dr. Sc.
Rok vydání: 2010
Typ publikace: Článek v odborném periodiku
Periodikum: Journal of Neuroscience
Bibliografická citace: JIRUŠKA, P., CSICSVARI, J., POWELL, A.V., FOX, J.E., CHANG, W.C., VREUGDENHIL, M., LI, X., PALUŠ, Milan, BUJAN, A.F., DEARDEN, R.W., JEFFERYS, J. G. R. High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro. Journal of Neuroscience. 2010, 30(16), 5690-5701. ISSN 0270-6474. E-ISSN 1529-2401
Dostupné z: doi:10.1523/JNEUROSCI.0535-10.2010
DOI: 10.1523/JNEUROSCI.0535-10.2010
ID: 345018

Abstrakt

How seizures start is a major question in epilepsy research. We demonstrate the existence of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) and reduction in system complexity. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure.